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  10 Early Signs of HIV in Men: Scientifically Supported Evidence Fever: A low-grade fever (37.8–38.9°C) is one of the earliest signs of HIV, occurring as the immune system reacts to the virus. This fever is often accompanied by fatigue and a general feeling of malaise. It indicates the body's inflammatory response to the rapid replication of HIV in the bloodstream. Fatigue: HIV-induced inflammation can cause fatigue and low energy levels. Studies show that early HIV infection disrupts the body’s metabolism, leading to reduced stamina and persistent tiredness, even after adequate rest. Swollen Lymph Nodes: Lymphadenopathy, or swollen lymph nodes in the neck, armpits, or groin, is a common early symptom. Lymph nodes are part of the immune system and often enlarge when fighting infections like HIV. Sore Throat: Many men with acute HIV experience a sore throat due to the viral load in the throat and the resulting inflammation. This symptom can last for several weeks, m...